Veratramine , ≥98% , 60-70-8
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB39.20 | In Stock |
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| 5mg | RMB63.20 | In Stock |
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| 10mg | RMB95.20 | In Stock |
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| 25mg | RMB156.80 | In Stock |
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| 50mg | RMB279.20 | In Stock |
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| 100mg | RMB457.60 | In Stock |
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| 250mg | RMB759.20 | In Stock |
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| 1g | RMB1903.20 | In Stock |
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| others | Enquire |
PRODUCT Properties
| Melting point: | 122-1240C |
| alpha | D25 -71.8° (c = 1.21); D25 -70° (c = 1.56 in methanol) |
| Boiling point: | 529.83°C (rough estimate) |
| Density | 1.0393 (rough estimate) |
| refractive index | 1.6400 (estimate) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Soluble in DMSO (up to 12 mg/ml) or in Ethanol (up to 10 mg/ml) |
| form | solid |
| pka | 14.82±0.60(Predicted) |
| color | Tan |
| λmax | 268nm(lit.) |
| Merck | 14,9952 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 60-70-8 |
Description and Uses
This alkaloid occurs naturally in Veratrum grandi/lorum and V. viride and is also formed during the hydrolysis of Veratrosine (q.v.). It forms colourless crystals of the monohydrate from aqueous EtOH and has [α]19D - 70° (MeOH). The hydrochloride forms colourless plates from EtOH, m.p. 20l-2°C and the picrate, yellow plates, m.p. 217.5 - 218°C. Two non-phenolic hydroxyl groups and an imino group are present and the triacetyl derivative, m.p. 205.5-206°C; [α]14.5D + 37.8° (MeOH), on controlled hydrolysis furnishes the N-acetyl com_x0002_pound, m.p. 176-8°C. The O-acetate has also been prepared as colourless prisms from aqueous EtOH, m.p. 20l-2°C but it is still uncertain which of the hydroxyl groups is acetylated in this derivative. Treatment with methyl iodide in MeOH in the presence of sodium carbonate gives N-methylveratraminc methiodide, m.p. 268°C (dec.) from which the methochloride, m.p. 277°C can be obtained. On catalytic hydrogenation, the base furnishes the dihydro derivative, m.p. 198- 200°C; [α]27D + 27.4°, which forms the N-acetyl compound, m.p. 220-3°C; [α]28D + 81° and the triacetyl derivative, m.p. l89.5-190.5°C; [α]24D + 84°.
The hedgehog (Hh) signaling pathway, which is blocked by cyclopamine , plays a key role in morphogenesis and has potential applications in the treatment of cancer. Veratramine, a teratogenic steroidal alkaloid isolated from the corn lily (Veratrum sp.), is an analog of cyclopamine that can inhibit the Hh signaling-dependent proliferation of NIH/3T3 cells at 8 μM. Additionally, veratramine has anti-thrombotic activity as it dose dependently inhibits platelet aggregation in rabbits ex vivo. While it may be most useful as a signal transduction inhibitor for treating tumors, veratramine also induces serotonin release and inhibits its re-uptake in the CNS.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P501-P270-P264-P301+P310+P330-P405 |
| RIDADR | UN 2811 6.1/PG III |
| RTECS | YX5094000 |
| HS Code | 2933.39.4100 |
| HazardClass | 6.1 |
| PackingGroup | III |
| Hazardous Substances Data | 60-70-8(Hazardous Substances Data) |
