Eslicarbazepine , 98% , 104746-04-5

CAS NO.：104746-04-5

Empirical Formula: C15H14N2O2

Molecular Weight: 254.28

MDL number:

PRODUCT Properties

• Melting point: 188-190°C
• Boiling point: 431.3±55.0 °C(Predicted)
• Density: 1.336
• storage temp.: -20°C Freezer
• solubility: Chloroform (Slightly, Heated), Methanol (Slightly), Pyridine (Slightly)
• form: Solid
• pka: 13.75±0.20(Predicted)
• color: White to Pale Yellow
• InChI: InChI=1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)/t14-/m0/s1
• InChIKey: BMPDWHIDQYTSHX-AWEZNQCLSA-N
• SMILES: N1(C(N)=O)C2=CC=CC=C2[C@@H](O)CC2=CC=CC=C12

Description and Uses

Eslicarbazepine (also known as (S)-10-Monohydroxy-10,11-dihydro Carbamazepine) is a voltage-gated sodium channel (Nav) inhibitor and the active metabolite of the prodrug eslicarbazepine acetate. It enhances the slow activation of voltage-gated sodium channels, thereby reducing channel availability. Eslicarbazepine is an oral anticonvulsant used as an adjunctive treatment for partial-onset seizures.

(S)-10-Monohydroxy-10,11-dihydro Carbamazepine is the metabolite of Eslicarbazepine acetate, (BIA 2-093), (E659000) a novel central nervous system drug.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P301+P312-P302+P352-P304+P340-P305+P351+P338