2-Amino-2-(2H-tetrazol-5-yl)aceticacid , 95% , 138199-51-6

CAS NO.：138199-51-6

Empirical Formula: C3H5N5O2

Molecular Weight: 143.1

MDL number: MFCD00233633

PRODUCT Properties

• Boiling point: 447.1±55.0 °C(Predicted)
• Density: 1.804±0.06 g/cm3(Predicted)
• storage temp.: Store at RT
• solubility: DMSO: 0.25mg/mL; PBS (pH 7.2): 0.2mg/mL
• form: Powder
• pka: 1.04±0.10(Predicted)
• Water Solubility: Soluble to 50 mM in water

Description and Uses

Tetrazolyl glycine is an NMDA receptor agonist. It binds to rat brain membranes with IC₅₀ values of 98 and 36 nM for [³H]CGS19755 and [³H]glutamate, respectively, in radioligand binding assays. It induces depolarization in rat cortical slices, an effect that is blocked by the NMDA receptor antagonist LY233053. It induces degeneration of GABAergic and cholinergic neurons in the striatum of adult rats and the formation of excitotoxic lesions and seizures in neonatal rats (ED₅₀ = 0.071 mg/kg). Intrastriatal injection of tetrazolyl glycine (5 μM) increases COX-2 expression in striatal neurons and the vasculature near the striatal injection site in a mouse model of excitotoxicity-induced neuronal injury.

(RS)-(Tetrazol-5-yl)glycine is a highly potent NMDA receptor agonist demonstrating ~ 20X more activity than NMDA.