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M2162547

LosartanCarboxaldehyde , 95% , 114798-36-6

Synonym(s):
2-Butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde;2-Butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imidazole-5-carbaldehyde;EXP-3179

CAS NO.:114798-36-6

Empirical Formula: C22H21ClN6O

Molecular Weight: 420.89

MDL number:

Pack Size Price Stock Quantity
5mg RMB558.40 In Stock
25mg RMB870.40 In Stock
100mg RMB2630.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 84-86°C
Boiling point: 666.7±65.0 °C(Predicted)
Density  1.34±0.1 g/cm3(Predicted)
storage temp.  Refrigerator, Under Inert Atmosphere
solubility  Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form  Solid
pka 4.16±0.10(Predicted)
color  Off-White to Light Yellow
CAS DataBase Reference 114798-36-6

Description and Uses

Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan . It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions. At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A2 and prostaglandin F . Losartan carboxaldehyde can also act as a partial agonist (EC50 = 17.1 μM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.

A labelled intermediate in the synthesis of the EXP 3174, a metabolite of Losartan

Safety

HS Code  2933290000

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