LosartanCarboxaldehyde , 95% , 114798-36-6

Synonym(s):
2-Butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde;2-Butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imidazole-5-carbaldehyde;EXP-3179

CAS NO.：114798-36-6

Empirical Formula: C22H21ClN6O

Molecular Weight: 420.89

MDL number:

PRODUCT Properties

• Melting point: 84-86°C
• Boiling point: 666.7±65.0 °C(Predicted)
• Density: 1.34±0.1 g/cm3(Predicted)
• storage temp.: Refrigerator, Under Inert Atmosphere
• solubility: Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
• form: Solid
• pka: 4.16±0.10(Predicted)
• color: Off-White to Light Yellow

Description and Uses

Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan . It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions. At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A₂ and prostaglandin F_2α . Losartan carboxaldehyde can also act as a partial agonist (EC₅₀ = 17.1 μM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.

A labelled intermediate in the synthesis of the EXP 3174, a metabolite of Losartan

Safety

• HS Code: 2933290000