Degrasyn(WP1130) , 99% , 856243-80-6
CAS NO.：856243-80-6
Empirical Formula: C19H18BrN3O
Molecular Weight: 384.27
MDL number: MFCD18839228
EINECS: 604-604-1
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB496.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Density | 1.358 |
| storage temp. | -20° |
| solubility | Soluble in DMSO (up to 45 mg/ml), or in Ethanol (up to 25 mg/ml). |
| form | solid |
| color | Yellow |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
Description and Uses
WP1130 (856243-80-6) is a novel DUB inhibitor directly inhibiting USP9x, USP5, USP14 and UCH37 inducing rapid accumulation of polyubiquitinated proteins. Triggers tumor cell apoptosis.1 Blocks Jak2 signaling via Jak2 ubiquitination.2 WP-1130 causes ablation of the oncogenic transcription factor ERG in prostate cancer cells.3 See methyl analog WP1066.
(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylbutyl]-2-propenamide can be used in biological study of drug screening and proteomic and metabolomic profiling to identify drug action mechanisms of breast cancer impaired pathogenicity.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
