Chlorcyclizinehydrochloride? , ≥99% , 14362-31-3

Synonym(s):
1-[(4-Chlorophenyl)phenylmethyl]-4-methylpiperazine monohydrochloride

CAS NO.：14362-31-3

Empirical Formula: C18H22Cl2N2

Molecular Weight: 337.29

MDL number: MFCD00035329

EINECS: 238-335-1

PRODUCT Properties

• Melting point: 226-227 °C
• storage temp.: Store at -20°C
• solubility: ≥11 mg/mL in DMSO with gentle warming; ≥14.7 mg/mL in EtOH; ≥9.44 mg/mL in H2O with ultrasonic
• form: Solid
• color: White to off-white
• InChI: InChI=1S/C18H21ClN2.ClH/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16;/h2-10,18H,11-14H2,1H3;1H
• InChIKey: MSIJLVMSKDXAQN-UHFFFAOYSA-N
• SMILES: C(C1C=CC=CC=1)(N1CCN(C)CC1)C1C=CC(Cl)=CC=1.Cl

Description and Uses

Chlorcyclizine Hydrochloride, often marketed under trade names such as Ahist and Histade, is a first-generation antihistamine primarily used for its anticholinergic and sedative properties. This medication is widely recognized in treating various allergic conditions, including allergic rhinitis and urticaria. It acts on H1 histamine receptors, which play a crucial role in allergic responses. Several research institutions have conducted extensive studies to understand its efficacy and safety profile. The drug was first synthesized in the 1940s and has since been a staple in allergy relief therapy. Although first-generation antihistamines are often overshadowed by second-generation counterparts due to their sedative effects, Chlorcyclizine Hydrochloride remains a valuable option for individuals seeking rapid and effective symptom relief.

An antihistaminic drug

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301-H315-H319-H335
• Precautionary statements: P301+P310+P330-P302+P352-P305+P351+P338
• Hazard Codes: T
• Risk Statements: 61-22
• Safety Statements: 53-22-36/37/39-45
• RIDADR: UN 2811 6.1 / PGIII
• Toxicity: cat,LD50,intraperitoneal,75mg/kg (75mg/kg),"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 213, 1972.