Bromopride? , 98% , 4093-35-0

CAS NO.：4093-35-0

Empirical Formula: C14H22BrN3O2

Molecular Weight: 344.25

MDL number: MFCD00078959

EINECS: 223-842-2

PRODUCT Properties

• Melting point: 148-150?C
• Boiling point: 435.8±45.0 °C(Predicted)
• Density: 1.4132 (rough estimate)
• refractive index: 1.6200 (estimate)
• storage temp.: 2-8°C
• solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• form: Solid
• pka: 13.84±0.46(Predicted)
• color: White to Off-White

Description and Uses

Bromopride is a dopamine D₂ receptor antagonist (K_i = 14 nM). It binds to bovine anterior pituitary membranes with an IC₅₀ value of 2.13 μM. Bromopride inhibits cholinesterase activity in vitro in rat plasma and striatum homogenate (IC₅₀s = 67.8 and 38.4 μM, respectively). It increases serum prolactin levels in rats by 100% when used at a dose of 0.02 mol/kg. Bromopride (2.5 mg/kg) decreases locomotion and rearing in an open field test and impairs acquistion, but not retention, of a conditioned avoidance response in a two-way active conditioned avoidance test in rats.

An antiemetic.Bromopride is used in method and a system for analyzing neuropharmacology of a drug.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H312-H332
• Precautionary statements: P280
• Hazard Codes: Xn
• Risk Statements: 20/21/22
• Safety Statements: 36
• WGK Germany: 3
• RTECS: BZ3280000