BMS806 , 99% , 357263-13-9
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB536.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 236 °C |
| Density | 1.328 |
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; insoluble in EtOH; ≥20.2 mg/mL in DMSO |
| form | solid |
| pka | 11.99±0.40(Predicted) |
| color | White to off-white |
Description and Uses
BMS-806 is a small molecule that inhibits the first step of HIV-1 infection by blocking the binding of host cell CD4 with viral gp120 protein. It binds the exterior envelope glycoprotein gp120 (Kd= 21.1 nM; Ki = 24.9 nM), blocking the conformational change that occurs with CD4 binding and preventing fusion of the viral and target cell membranes. BMS-806 is specific to HIV-1 irrespective of chemokine receptor preference, with no activity against HIV-2, SIV, or a panel of additional viruses.
BMS 806 is a small molecular inhibitor of HIV-1 virus which blocks the interaction between gp120 and CD4 cells.
