1-(1-Naphthyl)piperazine(hydrochloride) , 104113-71-5

CAS NO.：104113-71-5

Empirical Formula: C14H17ClN2

Molecular Weight: 248.75

MDL number: MFCD00055161

PRODUCT Properties

• Melting point: 235-237 °C
• storage temp.: Store at -20°C
• solubility: H₂O: soluble
• form: needles
• color: white

Description and Uses

1-(1-Naphthyl)piperazine (1-NP) is a ligand for serotonin (5-hydroxytryptamine, 5-HT) receptors. It acts as an antagonist for 5-HT at 5-HT₁ and 5-HT₂ in rat cortical membranes with IC₅₀ values of 6 and 1 nM, respectively. 1-NP also blocks contraction in the rat fundus induced by either 5-HT or tryptamine (IC₅₀ = 1 nM for both agonists). 1-NP mimics the 5-HT₁ agonist 1-(m-trifluoromethylphenyl)piperazine (TFMPP, ) in decreasing 5-HT receptor turnover and increasing serum corticosterone, suggesting that, in the absence of 5-HT, 1-NP may act as an agonist of the 5-HT₁ receptor. However, in squirrel monkeys, 1-NP acts as a non-selective 5-HT receptor antagonist in altering operant behavior. 1-NP also binds to the human 5-HT₆ receptor with an affinity comparable to that of 5-HT (K_is = 120 and 100 nM, respectively).

1-(1-Naphthyl)piperazinemiddotHCl is a mixed agonist/antagonist of the serotonin receptors.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• WGK Germany: 3