98% , 13551-87-6

CAS NO.：13551-87-6

Empirical Formula: C7H11N3O4

Molecular Weight: 201.181

MDL number: MFCD00866600

EINECS: 2369316

PRODUCT Properties

• Melting point: 107-109°C
• Boiling point: 339.09°C (rough estimate)
• Density: 1.3983 (rough estimate)
• refractive index: 1.6500 (estimate)
• storage temp.: Refrigerator
• solubility: Chloroform (Slightly, Heated), Methanol (Slightly, Sonicated)
• form: Solid
• pka: 13.49±0.20(Predicted)
• color: Yellow to Orange

Description and Uses

Misonidazole is a nitroimidazole with radiosensitizing and antineoplastic properties. Nitroimidazoles, including misonidazole, specifically accumulate as nitro anion radicals and their metabolites in hypoxic cells. The metabolites of misonidazole can themselves be cytotoxic or they can increase the chemosensitivity and radiosensitivity of the target cells. Misonidazole and derivatives, including fluoromisonidazole, are used in the imaging of hypoxic regions in tumors and in the cardiovascular system.

Misonidazole can be used as a potential hypoxic cancer cell radiosensitizer and DNA binding and nicking agent. The metabolites of misonidazole can themselves be cytotoxic or they can increase the chemosensitivity and radiosensitivity of the target cells

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P330-P501