PRODUCT Properties
| Melting point: | 208-209° (dec) |
| alpha | D25 +69° (c = 0.5 in water) |
| Density | 1.3893 (rough estimate) |
| refractive index | 1.6390 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble |
| form | A solid |
| pka | 8.67 in water, 9.05 in 40% ethanol |
| color | White to off-white |
Description and Uses
Sparsomycin is a bacterial metabolite and a nucleoside analog of uracil that has been found in S. sparsogenes and has diverse biological activities. It is active against KB carcinoma cells, Gram-positive and Gram-negative bacteria, and fungi. Sparsomycin is an inhibitor of peptidyl transferase that interferes with tRNA binding to the A-site of the peptidyl transfer center and increases the binding of peptidyl-tRNA to the P-site. It inhibits protein synthesis in bacteria, archaea, and eukaryotes. Sparsomycin reduces tumor growth in a P388 mouse leukemia model and in a Walker 256 carcinosarcoma rat model.
Research tool for studying protein biosynthesis.
Safety
| Hazard Codes | T+ |
| Risk Statements | 28 |
| Safety Statements | 28-36/37-45 |
| RIDADR | UN 2811 6.1/PG 2 |
| RTECS | WG5850000 |
| Toxicity | LD50 in dogs, rats, mice (mg/kg): 0.5-1.0, 2.25, 4.32 i.v. (Ottenheijm, 1986); LD50 i.p. in mice: 2.4 mg/kg (Owen) |
