8-M-PDOT , ≥98% , 134865-70-6

CAS NO.：134865-70-6

Empirical Formula: C14H19NO2

Molecular Weight: 233.31

MDL number: MFCD00901636

PRODUCT Properties

• Boiling point: 447.8±45.0 °C(Predicted)
• Density: 1.09±0.1 g/cm3(Predicted)
• storage temp.: Store at RT
• solubility: Soluble to 50 mM in ethanol and to 100 mM in DMSO
• form: Powder
• pka: 15.87±0.20(Predicted)
• color: White to off-white

Description and Uses

8-M-PDOT is a melatonin receptor 2 (MT₂) agonist (K_i = 1.12 nM). It is 5.2-fold selective for MT₂ over MT₁ receptors in a radioligand binding assay. Striatal microinfusion of 8-M-PDOT (10 μg/μl) increases the percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in a rat model of rotenone-induced Parkinson''s disease.

AH 002 is a selective melatonin receptor agonist.