Cefepimedihydrochloride , 98% , 107648-80-6

CAS NO.：107648-80-6

Empirical Formula: C19H25ClN6O5S2

Molecular Weight: 553.49

MDL number: MFCD06795759

EINECS: 827-945-9

PRODUCT Properties

• Melting point: 230 °C (decomp)
• solubility: Water:10.0(Max Conc. mg/mL);17.5(Max Conc. mM); DMSO:6.0(Max Conc. mg/mL);10.5(Max Conc. mM)

Description and Uses

Cefepime Hydrochloride is the hydrochloride salt of a semi-synthetic, beta-lactamase-resistant, fourth-generation cephalosporin antibiotic derived from an Acremonium fungal species with broad-spectrum bactericidal activity. Administered parenterally, cefepime inhibits bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, resulting in a reduction of bacterial cell wall stability and cell lysis. This agent is more active against a variety of Gram-positive pathogens compared to third-generation cephalosporins.

Cefepime hydrochloride has been used as a pharmaceutical reference standard for the determination of analytes in pharmaceutical preparations by spectrophotometric and chromatographic techniques. Cefepime is commonly used in the treatment of severe atypical pneumonia and infections caused by multi-drug resistant microorganisms (e.g. Pseudomonas aeruginosa), and is also indicated for the empirical treatment of febrile neutropenia.

Safety

• Symbol(GHS): GHS08,GHS05
• Signal word: Danger
• Hazard statements: H314-H317-H334
• Precautionary statements: P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501-P261-P285-P304+P341-P342+P311-P501