LE300 , ≥98% , 274694-98-3

CAS NO.：274694-98-3

Empirical Formula: C20H22N2

Molecular Weight: 290.4

MDL number: MFCD00951284

PRODUCT Properties

• Melting point: >91°C (dec.)
• storage temp.: Store at RT
• solubility: DMSO: 26 mg/mL
• form: solid
• color: Off-White to Pale Beige
• Stability: Hygroscopic

Description and Uses

LE300 is a dopamine D₁-like receptor antagonist (K_is = 1.9 and 7.5 nM in CHO cell membranes expressing human dopamine D₁ and D₅ receptors, respectively) and antagonist of the serotonin (5-HT) receptor subtype 5-HT_2A (pA₂ = 8.32 in a rat tail artery assay). It is selective for dopamine D₁ and D₅ over D_2L and D_4.4 receptors (K_is = 44.7 and 109 nM, respectively). LE300 inhibits the conditioned avoidance response in the pole-jump test in rats (ED₅₀ = 0.94 mg/kg), which is predictive for antipsychotic-like activity. It also reduces locomotor activity in the open field test in rats (ED₅₀ = 0.74 mg/kg).

LE 300 is a potent and selective dopamine receptor antagonist.

Safety

• WGK Germany: 3