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A7016958

Bromocriptinemesylate , 10mMinDMSO , 22260-51-1

Synonym(s):
(+)-2-Bromo-12′-hydroxy-2′-(1-methylethyl)-5′-(2-methylpropyl)ergotaman-3′,6′-18-trione methanesulfonate salt;(+)-Bromocriptine methanesulfonate salt;2-Bromo-α-ergocryptine methanesulfonate salt;Bromocriptine mesylate salt

CAS NO.:22260-51-1

Empirical Formula: C33H44BrN5O8S

Molecular Weight: 750.7

MDL number: MFCD00069218

EINECS: 244-881-1

Pack Size Price Stock Quantity
1ml RMB796.80 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 192-196° (dec)
alpha  D20 +95° (c = 1 in methanol-methylene chloride)
storage temp.  2-8°C
solubility  H2O: 0.8 mg/mL
form  solid
pka 4.90(at 25℃)
color  white
optical activity [α]20/D +95°, c = 1 in methanol: methylene chloride (1:1)(lit.)
Merck  13,1400
BRN  4115238
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
InChIKey NOJMTMIRQRDZMT-JGYCFGIMSA-N
CAS DataBase Reference 22260-51-1(CAS DataBase Reference)

Description and Uses

Bromocriptine is a dopamine receptor agonist (Kis = 1,659, 12.2, 12.2, 59.7, and 1,691 nM for dopamine D1, D2, D3, D4, and D5 receptors, respectively). It also binds to the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1D (Kis = 12.9 and 10.7 nM, respectively), as well as α1-adrenergic receptors (Kis = 1.12-4.17 nM). Bromocriptine (5 mg/kg) restores locomotor activity, without inducing dyskinesia, in a macaque model of Parkinson’s disease induced by MPTP. Formulations containing bromocriptine have been used in the treatment of Parkinson''s disease, hyperprolactinemia-associated dysfunctions, and acromegaly.

2-Bromo-α-Ergocryptine is a dopamine receptor agonist. 2-Bromo-α-Ergocryptine is a derivative of the ergotoxin group of ergot alkaloids. 2-Bromo-α-Ergocryptine is a prolactin inhibitor; antiparkinsoni an.

Safety

Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H302-H410
Precautionary statements  P273-P301+P312+P330
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  22-24/25-36
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
RTECS  KE1595000
3-10
HS Code  29396900
Toxicity LD50 in mice, rats, rabbits (mg/kg): 190, 72, 12.5 i.v. (Parkes)

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