Ilimaquinone , ≥98% , 71678-03-0

Synonym(s):
3-[(Decahydro-1β,2β,4aβ-trimethyl-5-methylene-1-napthyl)methyl]-2-hydroxy-5-methoxybenzoquinone, IQ;Ilimaquinone - CAS 71678-03-0 - Calbiochem

CAS NO.：71678-03-0

Empirical Formula: C22H30O4

Molecular Weight: 358.47

MDL number: MFCD22200891

PRODUCT Properties

• Melting point: 108-110℃ (pentane )
• alpha: D23 -23.2° (c = 1.12 in CHCl3)
• Boiling point: 478.4±45.0 °C(Predicted)
• Density: 1.14±0.1 g/cm3(Predicted)
• storage temp.: −20°C
• solubility: DMSO: Soluble; Ethanol: Soluble; Hexane: Soluble; Methanol: Soluble
• pka: 2.92±0.50(Predicted)
• form: Red solid
• color: Light yellow to brown

Description and Uses

Ilimaquinone is a natural sesquiterpene quinone that has antimicrobial, anti-HIV, anti-mitotic, and anti-inflammatory properties. In mammalian cells, 25 μM ilimaquinone reversibly induces vesiculation of Golgi membranes, blocking the secretory pathway. It inhibits the conversion of S-adenosylhomocysteine (SAH) to homocysteine by SAH hydrolase (IC₅₀ = 40 μM). Ilimaquinone also inhibits DNA polymerase β and dual specificity phosphatase Cdc25B (IC₅₀ = 45.2 and 92 μM, respectively) and, at 10 μM, activates gene expression through hypoxia-inducible factor-1.

Biological probe for intracellular communications and vesicle-mediated transport.

Safety

• WGK Germany: 3