Pirlindole , ≥98% , 60762-57-4

CAS NO.：60762-57-4

Empirical Formula: C15H18N2

Molecular Weight: 226.32

MDL number: MFCD00407230

PRODUCT Properties

• storage temp.: Store at RT
• solubility: DMF: 1 mg/ml; DMSO: 5 mg/ml
• form: A crystalline solid
• color: Off-white to light yellow

Description and Uses

Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor (IC₅₀s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively). It is selective for MAO-A over MAO-B (K_is = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively). In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3), inhibiting the genome replication phase of CV-B3 infection with an EC₅₀ value of 7.7 μM independent of MAO-A activity.

Antidepressive;Monoamine oxidase inhibitor

Safety

• HazardClass: IRRITANT