MarcfortineA , ≥98% , 75731-43-0

CAS NO.：75731-43-0

Empirical Formula: C28H35N3O4

Molecular Weight: 477.602

MDL number:

PRODUCT Properties

• Melting point: 245 °C
• Boiling point: 660.6±55.0 °C(Predicted)
• Density: 1.33±0.1 g/cm3(Predicted)
• storage temp.: Store at -20°C
• solubility: Methanol: soluble
• form: A solid
• pka: 12.05±0.60(Predicted)

Description and Uses

Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus (LD₉₉ = 0.06 μg/ml) and inhibits motility of adult worms (EC₅₀ = 2 μM)., Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED₉₅s = 0.33, 0.11, and 2.5 mg/animal, respectively). It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α₃ subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.

Marcfortine A is an indole alkaloid isolated from Aspergillus and Pencillium species.