CAY10486 , ≥98% , 615264-52-3

CAS NO.：615264-52-3

Empirical Formula: C19H19NO4

Molecular Weight: 325.36

MDL number: MFCD08062178

PRODUCT Properties

• storage temp.: Store at -20°C
• solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:5): .5 mg/ml; Ethanol: 20 mg/ml
• form: A crystalline solid

Description and Uses

Acyl-Coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10486 inhibits human ACAT-1 and ACAT-2 equally with an IC₅₀ value of approximately 60 μM. It also inhibits copper-mediated oxidation of low density lipoproteins by about 28% at a concentration of 3 μM.