Ro60-0175fumarate , ≥98% , 169675-09-6

CAS NO.：169675-09-6

Empirical Formula: C15H16ClFN2O4

Molecular Weight: 342.75

MDL number: MFCD06798313

PRODUCT Properties

• storage temp.: Desiccate at RT
• solubility: Soluble to 5 mM in water and to 20 mM in DMSO
• form: Powder
• color: White to off-white

Description and Uses

Ro 60-0175 is an agonist of the serotonin (5-HT) receptor subtype 5-HT₂ that stimulates increases in intracellular calcium levels in CHO-K1 cells expressing human 5-HT_2A, 5-HT_2B, and 5-HT_2C receptors (EC₅₀s = 447, 0.9, and 32 nM, respectively). It is selective for human 5-HT_2A and 5-HT_2C (K_is = 32 and 1 nM, respectively) over human 5-HT_1A, 5-HT_1D, 5-HT₆, and 5-HT₇, rat 5-HT_1B and 5-HT₃, and guinea pig 5-HT₄ receptors (K_is = ≥1,995 nM), as well as adenosine A₁ and A₂, histamine H_1-3, dopamine D_1-5, α₁-, α₂-, and β₁-adrenergic, M_1-5 muscarinic, nicotinic, kainate, AMPA, and μ-, δ-, and κ-opioid receptors (IC₅₀s = >1,000 nM), but does bind to β₂-adrenergic receptors (IC₅₀ = 251 nM). In vivo, Ro 60-0175 increases plasma levels of corticosterone, oxytocin, and prolactin in rats (ED₅₀s = 2.43, 4.19, and 4.03 mg/kg, respectively), effects that are not inhibited by the 5-HT_2C antagonist SB-242084 or the 5-HT_2A antagonist MDL 100,907 (volinanserin; ).

Ro 60-0175 fumarate is a potent and selective SR-2 agonist.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P