HydroxyPioglitazone , ≥98% , 146062-44-4

CAS NO.：146062-44-4

Empirical Formula: C19H20N2O4S

Molecular Weight: 372.44

MDL number: MFCD00916074

PRODUCT Properties

• Melting point: 157-1580C
• Boiling point: 627.6±55.0 °C(Predicted)
• Density: 1.325±0.06 g/cm3(Predicted)
• storage temp.: -20°C Freezer, Under Inert Atmosphere
• solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
• pka: 6.35±0.50(Predicted)
• form: Solid
• color: White to Off-White
• Stability: Hygroscopic

Description and Uses

Hydroxy pioglitazone is a major metabolite of the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone (Item Nos. 71745 | 22263 | 10028). It is formed from pioglitazone by the cytochrome P450 (CYP) isoform CYP2C8 with minor contributions from CYP3A4. Hydroxy pioglitazone binds to PPARγ (K_i = 1.2 μM) and activates PPARγ in a time-resolved FRET (TR-FRET) assay (EC₅₀ = 2.1 μM).

A metabolite of Pioglitazone (P471000).