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LN3058749

HydroxyPioglitazone , ≥98% , 146062-44-4

CAS NO.:146062-44-4

Empirical Formula: C19H20N2O4S

Molecular Weight: 372.44

MDL number: MFCD00916074

Pack Size Price Stock Quantity
1mg RMB2648.00 In Stock
5mg RMB7940.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 157-1580C
Boiling point: 627.6±55.0 °C(Predicted)
Density  1.325±0.06 g/cm3(Predicted)
storage temp.  -20°C Freezer, Under Inert Atmosphere
solubility  DMSO (Slightly), Methanol (Slightly, Sonicated)
pka 6.35±0.50(Predicted)
form  Solid
color  White to Off-White
Stability: Hygroscopic
CAS DataBase Reference 146062-44-4

Description and Uses

Hydroxy pioglitazone is a major metabolite of the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone (Item Nos. 71745 | 22263 | 10028). It is formed from pioglitazone by the cytochrome P450 (CYP) isoform CYP2C8 with minor contributions from CYP3A4. Hydroxy pioglitazone binds to PPARγ (Ki = 1.2 μM) and activates PPARγ in a time-resolved FRET (TR-FRET) assay (EC50 = 2.1 μM).

A metabolite of Pioglitazone (P471000).

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