AnsamitocinP-3 , 98% , 66547-09-9
CAS NO.：66547-09-9
Empirical Formula: C32H43ClN2O9
Molecular Weight: 635.14
MDL number: MFCD01939731
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB376.00 | In Stock |
|
| 10mg | RMB704.00 | In Stock |
|
| 20mg | RMB1200.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 182-185℃ |
| Boiling point: | 837.6±65.0 °C(Predicted) |
| Density | 1.30±0.1 g/cm3 (20 ºC 760 Torr) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml with warming). |
| pka | 9.83±0.70(Predicted) |
| form | White to off-white crystalline solid. |
| color | White |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
Description and Uses
Ansamitocin P-3 is a microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria. It binds tubulin (Kd = 1.3 μM), depolymerizes microtubules in both interphase and mitosis, and perturbs chromosome segregation. Ansamitocin P-3 also activates the spindle checkpoint surveillance proteins Mad2 and BubR1, blocking cell cycling during mitosis. It inhibits the growth of cancer cells in culture and significantly suppresses the growth of several cancer tumors in mice, prolonging survival time.
Ansamitocin P-3’ is a metabolite of Ansamitocin which is a new maytansinoid antitumor antibiotic.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| Hazard Codes | Xn |
| Risk Statements | 20/22-36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | OQ2293000 |
