PRODUCT Properties
| Melting point: | 71-73° |
| Boiling point: | 324.47°C (rough estimate) |
| Density | 1.1596 (rough estimate) |
| refractive index | 1.5012 (estimate) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| pka | -1.86±0.40(Predicted) |
| color | White to Off-White |
| Water Solubility | 4.2g/L(25 ºC) |
Description and Uses
Phensuximide is an anticonvulsant. It inhibits seizures induced by maximal electroshock (MES) and pentylenetetrazole in mice (ED50s = 112 and 50 mg/kg, respectively). Phensuximide (1.25 mmol/kg, i.p.) induces proteinuria and hematuria in rats. Formulations containing phensuximide have been used in the treatment of petit mal seizures.
Phensuximide, like ethosuximide, is an anticonvulsant drug used in minor forms of epilepsy.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| HS Code | 2925190100 |
| Toxicity | LD50 orally in mice: 960 mg/kg (Chen, Ensor) |
