LN-971430
Picotamide , 32828-81-2
Synonym(s):
4-Methoxy-N,N′-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide
Update time: 2023-04-23
PRODUCT Properties
| Melting point: | 128-131℃ |
| Boiling point: | 668.1±55.0 °C(Predicted) |
| Density | 1.246±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming). |
| pka | 13.31±0.46(Predicted) |
| form | White solid. |
| color | White |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
Description and Uses
Picotamide is an unique antithrombotic agent which acts by selectively inhibiting thromboxane synthesis and blocking platelet thromboxane receptors without affecting prostaglandin synthesis. It is reported to be useful in the treatment of myocardial infarction, cerebrovascular disorders, pulmonary embolism and atherosclerosis.
Keratolytic.
Safety
| Hazard statements | H303 |
| Precautionary statements | P270-P301+P312-P403-P501c |
| WGK Germany | 2 |
| RTECS | CZ2235500 |
| Toxicity | LD50 i.p. in male mice: 1205 mg/kg (Orzalesi, Selleri, 1976) |
