LEUROSINE , 0.95 , 23360-92-1

CAS NO.：23360-92-1

Empirical Formula: C46H56N4O9

Molecular Weight: 808.97

MDL number: MFCD01716248

PRODUCT Properties

• Melting point: 202-205℃
• Density: 1.39
• pka: 11.36±0.60(Predicted)

Description and Uses

Vinqa rosea yields this complex dimeric alkaloid which forms colourless crystals that are best purified by recrystallization from acetonitrile. It crystallizes with 8 moles of H20 and loses solvent when heated at In-5°C. It is also dextro? rotatory with [α]²⁶_D + n° (CHCI3)’ A crystalline SUlphate is known which has m.p. 238-242°C (dec.) and [α]_D - 8.3° (MeOH). The N(b)-oxide is identical with pleurosine (q.v.).

Antineoplastic.

Safety

• RIDADR: 1544
• HazardClass: 6.1(a)
• PackingGroup: II
• Hazardous Substances Data: 23360-92-1(Hazardous Substances Data)
• Toxicity: dog,LDLo,intraperitoneal,12mg/kg (12mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA",Eksperimental'naya Onkologiya. Experimental Oncology. Vol. 9(5), Pg. 76, 1987.