LN-834634
LEUROSINE , 0.95 , 23360-92-1
Update time: 2023-04-23
PRODUCT Properties
| Melting point: | 202-205℃ |
| Density | 1.39 |
| pka | 11.36±0.60(Predicted) |
Description and Uses
Vinqa rosea yields this complex dimeric alkaloid which forms colourless crystals that are best purified by recrystallization from acetonitrile. It crystallizes with 8 moles of H20 and loses solvent when heated at In-5°C. It is also dextro? rotatory with [α]26D + n° (CHCI3)’ A crystalline SUlphate is known which has m.p. 238-242°C (dec.) and [α]D - 8.3° (MeOH). The N(b)-oxide is identical with pleurosine (q.v.).
Antineoplastic.
Safety
| RIDADR | 1544 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| Toxicity | dog,LDLo,intraperitoneal,12mg/kg (12mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA",Eksperimental'naya Onkologiya. Experimental Oncology. Vol. 9(5), Pg. 76, 1987. |
