LN-731621
Thalicarpine , 99% , 5373-42-2
Update time: 2023-04-23
PRODUCT Properties
| Melting point: | 160-161° |
| alpha | D25 +133° (c = 0.83 in methanol); D25 +89° (c = 0.88 in chloroform) |
| Boiling point: | 701.43°C (rough estimate) |
| Density | 1.1544 (rough estimate) |
| refractive index | 1.4670 (estimate) |
| pka | 7.62±0.40(Predicted) |
Description and Uses
A complex alkaloid, thaliblastine occurs in Thalictrum minus elatum and has been assigned the structure given on the basis of chemical and spectroscopic investigations. The alkaloid has marked antitumour activity but rapid administration of the base causes brachycardia, hypotension and inhibition of respiration in laboratory animals. Slow intravenous injection, however, produces none of these effects. Thaliblastine is cytotoxic to HEF and Sa9 cells in vitro.
