LN-713627
ascofuranone , >98% , 38462-04-3
Update time: 2023-04-23
PRODUCT Properties
| Melting point: | 84 °C |
| Boiling point: | 581.2±50.0 °C(Predicted) |
| Density | 1?+-.0.06 g/cm3(Predicted) |
| pka | 6.32±0.50(Predicted) |
| color | Needles from Me2CO/hexane |
Description and Uses
(-)-Ascofuranone is an antibiotic with antitumor activity. It suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms. (-)-Ascofuranone was effective in the treatment against Trypanosoma brucei brucei infection in mice.
Safety
| Toxicity | LD50 ipr-rat: 1350 mg/kg JANTAJ 26,681,73 |
