LN-703731
Didemnin B , 97% Min. , 77327-05-0
CAS NO.：77327-05-0
Empirical Formula: C57H89N7O15
Molecular Weight: 1112.36
MDL number: MFCD01677226
Update time: 2023-04-23
PRODUCT Properties
| Boiling point: | 821.94°C (rough estimate) |
| Density | 1.0596 (rough estimate) |
| refractive index | 1.6910 (estimate) |
| storage temp. | Store at -20°C |
| solubility | Acetonitrile: 1 mg/ml |
| form | A crystalline solid |
| pka | 11.28±0.70(Predicted) |
| color | White to off-white |
| optical activity | -82.0622 (CHCl3) |
Description and Uses
Didemnin B is a cyclic depsipeptide extracted from the Caribbean tunicate Trididemnum cyanophorum. Didemnin B activates caspase, inducing apoptosis and preventing eukaryotic elongation factor 2 (eEF-2)-dependent translocation, inhibiting protein synthesis. This agent also has immunosuppressive and antiviral properties. It is an effective immunosuppressive agent. It is approximately 1,000 times more effective than the standard cyclosporin A. Further study may prove it useful in repressing rejections of transplanted organs[1].
Safety
| Symbol(GHS) |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H319-H400-H410 |
| Precautionary statements | P264-P273-P280-P305+P351+P338-P337+P313-P391-P501 |
