ATRACTYLOSIDE SODIUM SALT , 99.9% , 100938-11-2
CAS NO.：100938-11-2
Empirical Formula: C30H44Na2O16S2
Molecular Weight: 770.77
MDL number: MFCD00171231
Description and Uses
A specific inhibitor of the adenine nucleotide translocase (ANT), which is a mitochondrial ADP/ATP carrier. It is also a proapoptotic ligand of ANT that induces pore formation by ANT, and results in p ermeabilization of the mitochondria membrane. Studies on rat hearts suggest that Atractyloside inhibits chloride channels from the mitochondrial membrane. It is used to probe the source of procaspase 8 in human fibroblasts and mouse clonal striatal cells, as related to death receptor-mediated apoptosis. ATRACTYLOSIDE SODIUM SALT induces the release of ahyaluronidase-induced murine WW domain-containing oxidore ductase from cultured COS-7 cells, with respect to tumor necrosis factor cytotoxicity.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H331-H311-H301 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501-P261-P271-P304+P340-P311-P321-P403+P233-P405-P501-P280-P302+P352-P312-P322-P361-P363-P405-P501 |
| Hazard Codes | T |
| Risk Statements | 23/24/25 |
| Safety Statements | 36/37/39-45 |
| RIDADR | 3172 |
| HazardClass | 6.1(a) |
| PackingGroup | I |
