Glycitein , 10mMinDMSO , 40957-83-3

Synonym(s):
4′,7-Dihydroxy-6-methoxyisoflavone;Glycetein

CAS NO.：40957-83-3

Empirical Formula: C16H12O5

Molecular Weight: 284.26

MDL number: MFCD00016679

PRODUCT Properties

• Melting point: >300°C
• Boiling point: 547.4±50.0 °C(Predicted)
• Density: 1.420±0.06 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: Aqueous Base (Slightly), DMSO (Slightly)
• form: Solid
• pka: 7.03±0.20(Predicted)
• color: Light Brown
• InChIKey: DXYUAIFZCFRPTH-UHFFFAOYSA-N
• LogP: 2.570 (est)

Description and Uses

Glycitein is an O-methylated isoflavone that comprises 5-10% of the total isoflavones in soy food products. This phytoestrogen is reported to have weak estrogenic activity, displacing estradiol binding at the estrogen receptor in vitro with an IC₅₀ value of 3.94 μM. It suppresses the proliferation of osteoblasts and promotes differentiation from its progenitor. It has also been used to attenuate proliferation (10 μM) of aortic smooth muscle cells related to atherosclerotic vascular change in stroke-prone hypertensive rats and to protect against beta amyloid (Aβ)-induced toxicity and oxidative stress (100 μg/ml) in C. elegans expressing human Aβ.

Glycitein has been used as standard for the analysis of soy isoflavones and metabolites in urine. It has also been used to bind to recombinant estrogen and progesterone receptors to know the relative binding affinity (RBA) for detection of potential endocrine disruptors.

Safety

• Symbol(GHS): GHS05,GHS06
• Signal word: Danger
• Hazard statements: H301-H311-H314-H331
• Precautionary statements: P260-P264-P270-P271-P280-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P310-P403+P233-P405-P501
• Hazard Codes: Xi
• Safety Statements: 24/25
• WGK Germany: 3
• HS Code: 29329990