MMP SUBSTRATE III, FLUOROGENIC , 99% , 193475-71-7

CAS NO.：193475-71-7

Empirical Formula: C63H88N16O14S

Molecular Weight: 1325.54

MDL number: MFCD02094711

PRODUCT Properties

• Density: 1.40±0.1 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: DMSO: soluble; Tris-buffered saline, pH 7.6: soluble
• form: lyophilized solid
• pka: -0.26±0.40(Predicted)
• color: red

Description and Uses

TNO211 is a biological active peptide. (Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.)