LN-252134
Hydrocortisone IMpurity I , 0.95 , 103795-84-2
Update time: 2023-04-23
PRODUCT Properties
| Melting point: | 241-242 °C |
| Boiling point: | 602.3±55.0 °C(Predicted) |
| Density | 1.35±0.1 g/cm3(Predicted) |
| pka | 12.10±0.70(Predicted) |
Description and Uses
14α-Hydroxycortisol (Hydrocortisone EP Impurity I) is an impurity of Hydrocortisone (H714615), a topical corticosteroid (1), but more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland (2). Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
