LN-066324
Roxatidine , 0.99 , 78273-80-0
Update time: 2023-04-23
PRODUCT Properties
| Melting point: | 59-60 °C |
| Boiling point: | 524.3±45.0 °C(Predicted) |
| Density | 1.137±0.06 g/cm3(Predicted) |
| storage temp. | -20° |
| solubility | Soluble in DMSO (up to 25 mg/ml). |
| pka | 13.34±0.10(Predicted) |
| form | oil |
| color | Colorless to pale yellow |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| CAS DataBase Reference | 78273-80-0(CAS DataBase Reference) |
Description and Uses
Roxatidine (78273-80-0) is a novel histamine H2 receptor antagonist.1?Suppresses inflammatory responses via inhibition of NFκB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages.2?Clinically useful agent for prevention and healing of gastric and duodenal ulcers and bleeding.3?Attenuates degradation of extracellular matrix in osteoarthritis models by inactivating the NFkB pathway.4
Anti-ulcerative.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
