N-N-Dimethylacetamide , forHPLC,≥99.8%(GC) , 127-19-5
Synonym(s):
DMAC;N,N-Dimethylacetamide;N,N-Dimethylacetamide solution;N,N-Dimethylacetamide;N,N-Dimethylacetamide ZerO2
CAS NO.：127-19-5
Empirical Formula: C4H9NO
Molecular Weight: 87.12
MDL number: MFCD00008686
EINECS: 204-826-4
| Pack Size | Price | Stock | Quantity |
| 100ml | RMB47.20 | In Stock |
|
| 500ML | RMB75.20 | In Stock |
|
| 1L | RMB148.00 | In Stock |
|
| 4L | RMB415.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | -20 °C (lit.) |
| Boiling point: | 164.5-166 °C (lit.) |
| Density | 0.937 g/mL at 25 °C (lit.) |
| vapor density | 3.89 (vs air) |
| vapor pressure | 40 mm Hg ( 19.4 °C) |
| refractive index | n |
| Flash point: | 158 °F |
| storage temp. | Store below +30°C. |
| solubility | >1000g/l soluble |
| form | Liquid |
| pka | -0.41±0.70(Predicted) |
| color | Colorless to yellowish |
| PH | 4 (200g/l, H2O, 20℃) |
| Relative polarity | 6.3 |
| Odor | Faint ammonia odor |
| PH Range | 4 at 200 g/l at 20 °C |
| Odor Threshold | 0.76ppm |
| explosive limit | 1.7-11.5%(V) |
| Water Solubility | miscible |
| λmax | λ: 270 nm Amax: 1.00 λ: 280 nm Amax: 0.30 λ: 290 nm Amax: 0.15 λ: 310 nm Amax: 0.05 λ: 320 nm Amax: 0.03 λ: 360-400 nm Amax: 0.01 |
| Merck | 14,3227 |
| BRN | 1737614 |
| Exposure limits | NIOSH REL: TWA 10 ppm (35 mg/m3), IDLH 300 ppm; OSHA PEL: TWA 10
ppm; ACGIH TLV: TWA 10 ppm (adopted). |
| Dielectric constant | 37.8（25℃） |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| InChIKey | FXHOOIRPVKKKFG-UHFFFAOYSA-N |
| LogP | -0.77 at 25℃ |
| CAS DataBase Reference | 127-19-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetamide, N,N-dimethyl-(127-19-5) |
| IARC | 2B (Vol. 123) 2020 |
| EPA Substance Registry System | Dimethylacetamide (127-19-5) |
Description and Uses
Dimethylacetamide (DMAC) is a synthetic organic compound that is produced from a reaction of dimethylamine and acetic acid or acetic anhydride. It is a colorless to yellow liquid with a faint odor resembling ammonia. DMAC has similar density to water and is miscible with water and organic substances. This organic compound is commonly associated with many industrial uses, either as a starting material or an intermediate. DMAC is a good solvent that is used in polymer dissolution, especially in the fiber industry. Historically, DMAC was also tested as a possible antineoplastic agent in a phase 1 study involving 17 patients. However, liver and central nervous system (CNS) toxicity associated with DMAC was observed and these patients had altered mental states, resulting in no further drug development.
N,N-dimethylacetamide is an excellent solvent and often acts as a catalyst in halogenation, cyclization, and alkylation reactions. It is an important industrial solvent for polyacrylonitrile, vinyl resins, cellulose derivatives, styrene polymers and linear polyesters. It is also used in all analytical laboratories as a major component of mobile phase in High Performance Liquid Chromatography (HPLC) and in Liquid Chromatography - Mass Spectrometry (LC-MS). N,N-dimethylacetamide lithium chelate complexes intercalate cationic sites in layered silicates.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H312+H332-H319-H360D |
| Precautionary statements | P201-P280-P302+P352+P312-P304+P340+P312-P305+P351+P338-P308+P313 |
| Hazard Codes | T |
| Risk Statements | 11-20/22-61-20/21-36 |
| Safety Statements | 16-24-53-45-36-28-26 |
| OEB | A |
| OEL | TWA: 10 ppm (35 mg/m3) [skin] |
| RTECS | AB7700000 |
| F | 3-10 |
| Autoignition Temperature | 914 °F |
| HS Code | 29241900 |
| Hazardous Substances Data | 127-19-5(Hazardous Substances Data) |
| Toxicity | LD50 orally in rats: 5.4 ml/kg (Bartsch) |
| IDLA | 300 ppm |
