ICRF-186 , 0.95 , 24613-06-7

CAS NO.：24613-06-7

Empirical Formula: C11H16N4O4

Molecular Weight: 268.27

MDL number: MFCD00870253

Update time: 2023-04-23

PRODUCT Properties

Boiling point:	531.5±50.0 °C(Predicted)
Density	1.333±0.06 g/cm3(Predicted)
pka	11.00±0.20(Predicted)

Description and Uses

(R)-Levrazoxane ((R)-ICRF 186) is enzymatically hydrolysed to one-ring open intermediates by dihydropyrimidine amidohydrolase (DPHase), which is present in the liver and kidney. The radiosensitizing efficiency of (R)-Levrazoxane towards EMT6 mouse mammary tumour cells is greater than that of Dexrazoxane (HY-B0581). (R)-Levrazoxane is promising for research of liver and kidney related diseases[1].

Safety

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H302+H312+H332
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

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