2,2-Dichloro-1,1-difluoroethyl methyl ether , 97 , 76-38-0

Synonym(s):
2,2-Dichloro-1,1-difluoro-1-methoxyethane;hMOF;KAT8;MOF;MYST1

CAS NO.：76-38-0

Empirical Formula: C3H4Cl2F2O

Molecular Weight: 164.97

MDL number: MFCD00040144

EINECS: 200-956-0

PRODUCT Properties

• Melting point: -36°C
• Boiling point: 103 °C
• Density: 1.4262
• refractive index: 1.386
• Flash point: 37°C
• storage temp.: -70°C
• solubility: Chloroform (Sparingly)
• form: liquid
• color: Clear
• Water Solubility: Miscible with alcohol, acetone, chloroform, ether, fixed oils and benzene. Immiscible with water.
• Merck: 14,5994
• BRN: 1737766
• Exposure limits: No exposure limit is set. Based on comparison with related compounds, a TLV-TWA of 675 mg/m³ (100 ppm) is recommended.
• Stability: Stability

Description and Uses

Methoxyflurane, 2,2-dichloro- 1,1- difluoro-1-methoxyethane,is a colorless liquid with a fruity odor. It is produced industrially by the addition of methanol to 1,1-dichloro- 2,2-difluoroethylene in the presence of sodium methoxide .

Methoxyflurane is used as a clinical anesthesia (inhalation).

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Warning
• Hazard statements: H226-H319-H341
• Precautionary statements: P210-P241-P308+P311
• Hazard Codes: Xi
• Risk Statements: 10
• Safety Statements: 23-24/25
• RIDADR: 3271
• OEL: Ceiling: 2 ppm (13.5 mg/m3) [60-minute] [*Note: REL for exposure to waste anesthetic gas.]
• RTECS: KN7820000
• Hazard Note: Irritant
• HazardClass: 3
• PackingGroup: III
• HS Code: 2909191800
• Toxicity: One of the most potent of the inhalational anesthetics, having a very high blood-gas partition coefficient and low vapor pressure at room temperature. Methoxyflurane is metabolized to a great extent (about 50-70%) in the liver and, as a consequence, there may be release of high concentrations of fluoride, sufficient to exceed the threshold for renal damage. Its use for sustained anesthesia is limited because of this renal toxicity and was discontinued around 1980.