N-((S)-1-(((R)-1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide , 95+% , 289472-78-2

CAS NO.：289472-78-2

Empirical Formula: C19H24N4O3

Molecular Weight: 356.42

MDL number:

PRODUCT Properties

• Boiling point: 672.0±55.0 °C(Predicted)
• Density: 1.199±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• pka: 11.90±0.46(Predicted)
• form: Solid
• color: White to Off-White

Description and Uses

(R)-Hydroxy Des(boric acid) Bortezomib is an impurity in the synthesis of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.