4-Amino-2-fluoro-N-methylbenzamide , 98% , 915087-25-1

CAS NO.：915087-25-1

Empirical Formula: C8H9FN2O

Molecular Weight: 168.17

MDL number: MFCD09909322

PRODUCT Properties

• Melting point: 160 - 163°C
• Boiling point: 320℃
• Density: 1.234
• Flash point: 147℃
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• solubility: Chloroform (Slightly), Methanol (Slightly)
• form: Solid
• pka: 14.12±0.46(Predicted)
• color: White to Off-White
• Stability: Moisture Sensitive
• InChI: InChI=1S/C8H9FN2O/c1-11-8(12)6-3-2-5(10)4-7(6)9/h2-4H,10H2,1H3,(H,11,12)
• InChIKey: XOKAXPQJUODMSH-UHFFFAOYSA-N
• SMILES: C(NC)(=O)C1=CC=C(N)C=C1F

Description and Uses

4-amino-2-fluoro-N-methylbenzamide is a novel antiandrogen drug MDV (Marek's Disease Virus) 3100 key intermediate which is the new generation oral androgen antagonist medicine of united states drug developer Medivation company exploitation, be mainly used in treating advanced prostate cancer (CRPC) patient.

4-amino-2-fluoro-N-methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors.

Safety

• Signal word: Warning
• Hazard statements: H317-H319-H302
• Precautionary statements: P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
• HS Code: 2924297099