4,7,10,13-Tetraoxahexadec-15-yn-1-oicacid , 97% , 1415800-32-6

Synonym(s):
4,7,10,13-Tetraoxahexadec-15-ynoic acid;Propargyl-PEG4-CH₂CO₂H

CAS NO.：1415800-32-6

Empirical Formula: C12H20O6

Molecular Weight: 260.28

MDL number: MFCD22683284

PRODUCT Properties

• Boiling point: 388.0±37.0 °C(Predicted)
• Density: 1.129±0.06 g/cm3(Predicted)
• refractive index: n/D 1.460
• storage temp.: -20°C
• solubility: Soluble in Water, DMSO, DCM, DMF
• form: Viscous Liquid
• pka: 4.28±0.10(Predicted)
• color: Colorless to light yellow

Description and Uses

Propargyl-PEG4-acid is a PEG reagent with an alkyne and a terminal carboxylic acid. The carboxylic acid reacts with primary amine groups with the help of activators (e.g. EDC, or HATU). The 4-unit PEG spacer increases hydrophilicity. The alkyne can participate in copper-catalyzed Click Chemistry.

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.

Safety

• Symbol(GHS): GHS02
• Signal word: Danger
• Hazard statements: H242
• Precautionary statements: P210-P234-P235-P240-P370+P378-P403