3-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoicacid , 97% , 1347760-82-0

CAS NO.：1347760-82-0

Empirical Formula: C10H16O5

Molecular Weight: 216.23

MDL number: MFCD22201521

PRODUCT Properties

• storage temp.: -20°C
• solubility: Soluble in Water, DMSO, DCM, DMF
• form: clear liquid
• color: Light yellow to Brown

Description and Uses

Propargyl-PEG3-acid is a reagent with an alkyne group and a carboxylic acid. The terminal carboxylic acid can form amide bond with primary amines (activation is needed). The alkyne can form triazole linkage with azide containing molecules via copper catalyzed reactions.

Propargyl-PEG₃-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG₃-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H319-H315
• Precautionary statements: P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
• HS Code: 2918.99.5000