1,2-Bis[(2S,5S)-2,5-diethylphospholano]benzene(1,5-cyclooctadiene)rhodium(I)tetrafluoroborate , 98% , 213343-64-7

Synonym(s):
(S,S)-Et-DUPHOS-Rh

CAS NO.：213343-64-7

Empirical Formula: C30H46BF4P2Rh

Molecular Weight: 658.35

MDL number: MFCD03412156

PRODUCT Properties

• form: Powder
• color: Orange to red to brown
• Sensitive: air sensitive

Description and Uses

DuPhos and BPE Ligands: Highly Efficient Privileged Ligands

Catalyst for:

• Preparation of a key unit B precursor of cryptophycins via Horner-Wadsworth-Emmons reaction and asymmetric hydrogenation
• Preparation of constrained phenylalanine analogs via Heck reaction followed by asymmetric hydrogenation and cyclization steps
• Enantioselective preparation of N-benzyloxy-β-amino acid Me esters by hydrogenation of α-(benzyloxyaminomethyl)acrylate stereoisomers
• Preparation of fluoro amino acids as synthons for potent macrocyclic HCV NS3 protease inhibitors
• Stereoselective preparation of triply isotope-labeled Ser, Cys, and Ala
• Preparation of β-amino acids from asymmetric hydrogenation of α-(aminomethyl)acrylates
• Asymmetric hydrogenation of a-primary and secondary amino ketones and asymmetric synthesis of (-)-arbutamine and (-)-denopamine

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H319-H315-H335
• Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
• Risk Statements: 36/37/38
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• HS Code: 28439000