4-Thioxo-3,4-dihydropyrimidin-2(1H)-one , 98% , 591-28-6
Synonym(s):
2-Hydroxy-4-mercaptopyrimidine
Pack Size | Price | Stock | Quantity |
250mg | RMB102.40 | In Stock |
|
1g | RMB266.40 | In Stock |
|
5g | RMB1313.60 | In Stock |
|
others | Enquire |
PRODUCT Properties
Melting point: | 295 °C (dec.) (lit.) |
Density | 1.368 (estimate) |
refractive index | 1.7000 (estimate) |
storage temp. | Store at -20°C |
solubility | 1 M NaOH: soluble50mg/mL |
form | Powder |
pka | 5.38±0.20(Predicted) |
color | Yellow |
CAS DataBase Reference | 591-28-6(CAS DataBase Reference) |
Description and Uses
4-Thiouracil is a site-specific, photoactivatable probe used to detect RNA structures and nucleic acid-nucleic acid contacts. It absorbs ultraviolet light >300 nm and, in the presence of oxygen, acts as an energy donor to produce singlet oxygen by triplet-triplet energy transfer. The highly reactive oxygen species then reacts readily with 4-thiouracil, leading to the production of uracil and uracil-6-sulfonate, which is fluorescent at a wavelength of ~390 nm. 4-Thiouracil is used as a T. gondii uracil phosphoribosyltransferase substrate to produce 4-thiouridine monophosphate, which can ultimately be incorporated into RNA.
4-Thiouracil is suitable reagent employed in Schneider′s media for the embryos during RNA extraction. It may be employed as reagent for the Northwestern blotting technique.
Safety
Symbol(GHS) | GHS07 |
Signal word | Warning |
Hazard statements | H302+H312+H332 |
Precautionary statements | P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312 |
Hazard Codes | Xn |
Risk Statements | 20/21/22 |
Safety Statements | 36 |
WGK Germany | 3 |
HS Code | 29335990 |