(Z)-3-(Dimethylamino)propane-1,2-diyldioleate , 98% , 127512-29-2

Synonym(s):
1,2-dioleoyl-3-dimethylammonium-propane (DODAP)

CAS NO.：127512-29-2

Empirical Formula: C41H77NO4

Molecular Weight: 648.05

MDL number: MFCD01321074

PRODUCT Properties

• Boiling point: 670.1±55.0 °C(Predicted)
• Density: 0.916±0.06 g/cm3(Predicted)
• storage temp.: -20°C Freezer, Under Inert Atmosphere
• solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• form: Oil
• pka: 8.02±0.28(Predicted)
• color: Colourless to Light Yellow
• Stability: Light Sensitive; Hydroscopic; Store at -15 to -25°C
• InChIKey: NYDLOCKCVISJKK-WRBBJXAJSA-N
• SMILES: C(OC(=O)CCCCCCC/C=C\CCCCCCCC)(CN(C)C)COC(=O)CCCCCCC/C=C\CCCCCCCC

Description and Uses

DODAP (18:1) is an ionizable cationic lipid with lower cytotoxicity and high transfection efficiency. DODAP is neutral at physiological pH, but acquires a positive charge inside the endosome due to the protonation of free amines when pH is lower than its pKa (<7).

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H302-H315-H319-H331-H336-H351-H361d-H372
• Precautionary statements: P202-P301+P312-P302+P352-P304+P340+P311-P305+P351+P338-P308+P313