1,2,3,6-Tetrahydro-2,3'-bipyridine , 95% , 2743-90-0

CAS NO.：2743-90-0

Empirical Formula: C10H12N2

Molecular Weight: 160.22

MDL number: MFCD00078278

PRODUCT Properties

• Boiling point: 136
• Density: 1.045±0.06 g/cm3(Predicted)
• storage temp.: Amber Vial, Refrigerator, Under Inert Atmosphere
• solubility: ≤15mg/ml in DMSO;15mg/ml in dimethyl formamide
• form: solution in ethanol.
• pka: 8.84±0.40(Predicted)
• color: Light yellow to yellow
• Stability: Hygroscopic, Light Sensitive
• CAS DataBase Reference: 2743-90-0

Description and Uses

(R,S)-Anatabine is a minor alkaloid produced in plants of the Solanaceae family, including tobacco. The detection of (R,S)-anatabine in urine is used as an indicator of tobacco use, particularly when nicotine-containing products (gum, patches, inhalers, and medications) are also being used. (R,S)-Anatabine increases nicotine self-administration and locomotor activity in rats. Of note, (R,S)-anatabine diminishes amyloid-β production in vitro and in vivo. (R,S)-Anatabine reduces (600 μg/ml) the transcription and protein levels of β-secretase, lowering the amount of Aβ (1-40) and Aβ (1-42) in a dose dependent manner in SHSY-5Y cells. (R,S)-Anatabine also dose dependently inhibits NF-κB activation.

A nicotine (N412420) metabolite.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301-H319
• Precautionary statements: P264-P270-P280-P301+P310-P305+P351+P338-P337+P313
• Risk Statements: 25-36
• Safety Statements: 24/25
• RIDADR: 2810
• HazardClass: IRRITANT
• HS Code: 29399990