Home Categories 4-Amino-1,8-naphthalimide
BD8604947

4-Amino-1,8-naphthalimide , 95% , 1742-95-6

CAS NO.:1742-95-6

Empirical Formula: C12H8N2O2

Molecular Weight: 212.2

MDL number: MFCD00006921

EINECS: 217-110-1

Pack Size Price Stock Quantity
100mg RMB271.20 In Stock
250mg RMB460.00 In Stock
1g RMB1240.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 360 °C
Boiling point: 352.04°C (rough estimate)
Density  1.105 g/mL at 25 °C(lit.)
vapor pressure  0Pa at 25℃
refractive index  1.6000 (estimate)
storage temp.  -20°C
solubility  Soluble in DMSO
form  Orange solid.
pka 9.53±0.20(Predicted)
color  Yellow to brown
Water Solubility  354mg/L at 25℃
LogP 1.08
CAS DataBase Reference 1742-95-6
EPA Substance Registry System 1H-Benz[de]isoquinoline-1,3(2H)-dione, 6-amino- (1742-95-6)

Description and Uses

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. 4-amino-1,8-Naphthalimide (4-ANI) is an inhibitor of PARP (IC50 = 180 nM). It blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation. 4-ANI is used to study the role of PARP activity in various cell systems.

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. 4-amino-1,8-Naphthalimide (4-ANI) is an inhibitor of PARP (IC50 = 180 nM). It blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation. 4-ANI is used to study the role of PARP activity in various cell systems.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
WGK Germany  3
RTECS  DE4081000
TSCA  Yes
HS Code  29251995

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