Sciadopitysin , 98+% , 521-34-6

CAS NO.：521-34-6

Empirical Formula: C33H24O10

Molecular Weight: 580.54

MDL number: MFCD00017448

EINECS: 208-311-5

PRODUCT Properties

• Melting point: 296-298°C
• Boiling point: 839.6±65.0 °C(Predicted)
• Density: 1.445±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: Soluble in ethanol and methan
• form: powder
• pka: 6.16±0.40(Predicted)
• color: Light yellow
• LogP: 5.500 (est)
• CAS DataBase Reference: 521-34-6

Description and Uses

Sciadopitysin is a biflavonoid originally isolated from G. biloba and has diverse biological activities. It reduces cytotoxicity induced by amyloid-β (1-42) (Aβ42; ) in PC12 cells (EC₅₀ = 9.84 μM). Sciadopitysin (0.1-10 μM) decreases methylglyoxal-induced insulin secretion, production of reactive oxygen species (ROS), cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells. It inhibits P-glycoprotein (P-gp; IC₅₀ = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel in MDR1-MDCKII cells. Sciadopitysin inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss.

Safety

• Safety Statements: 24/25
• HS Code: 29329990