Valspodar , 99% , 121584-18-7
Synonym(s):
[3′-Desoxy-3′-oxo-MeBmt]1-[Val]2-cyclosporin;6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic acid]cyclosporin D;Amdray;PSC833
CAS NO.：121584-18-7
Empirical Formula: C63H111N11O12
Molecular Weight: 1214.62
MDL number: MFCD00907207
EINECS: 1312995-182-4
| Pack Size | Price | Stock | Quantity |
| 10mg | RMB3712.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 143-145°C |
| alpha | D20 -255.1° (c = 0.5 in CHCl3) |
| Boiling point: | 1290.1±65.0 °C(Predicted) |
| Density | 1.015±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 12.45±0.70(Predicted) |
| form | powder |
| color | white to beige |
| InChIKey | YJDYDFNKCBANTM-QCWCSKBGSA-N |
Description and Uses
PSC 833 is a non-immunosuppressant derivative of cyclosporine and potent multidrug-resistance (MDR) modulator. It restores sensitivity of MDR-P388 murine leukemia cells to cytostatic agents when used at concentrations of 70, 33, 45, 34, and 26 nM in combination with colchicine, vincristine , daunorubicin , doxorubicin , and etoposide , respectively. PSC 833 inhibits basal-to-apical transport and increases apical-to-basal transport of [14C]docetaxel in LLC-GA5-COLO150 cells that overexpress human P-glycoprotein (P-gp). In vivo, PSC 833 increases survival time in MDR-P388 tumor-bearing mice and in an MDR-L1210 leukemia mouse xenograft model when administered in combination with doxorubicin. PSC 833 also prolongs the anti-hyperalgesic effects of intraperitoneally administered pregabalin in a mouse model of cold stress-induced central pain.
Valspodar/ PSC-833 has been used as a ABCB1 (P-glycoprotein) inhibitor.
Safety
| WGK Germany | 3 |
