((3S,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl4-methylbenzenesulfonate , 98% , 149809-43-8

CAS NO.：149809-43-8

Empirical Formula: C21H21F2N3O4S

Molecular Weight: 449.47

MDL number: MFCD13195567

EINECS: 1308068-626-2

PRODUCT Properties

• Melting point: 100-102°C
• Boiling point: 608.1±65.0 °C(Predicted)
• Density: 1.40
• storage temp.: -20°C Freezer, Under Inert Atmosphere
• solubility: slightly sol. in Chloroform
• form: powder to crystal
• pka: 2.75±0.10(Predicted)
• color: White to Orange to Green
• InChIKey: DFWVLCJRFGIRAK-HRAATJIYSA-N
• CAS DataBase Reference: 149809-43-8(CAS DataBase Reference)

Description and Uses

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester is a pharmaceutical intermediate ingredient for Posaconazole is one of the newest triazole antifungal agents approved by the FDA for the prevention of invasive Aspergillus and Candida infections in immunocompromised patients. Such patients include haematopoietic stem cell transplant patients with graft-versus-host disease and patients with haematological malignancies undergoing chemotherapy.

Posaconazole intermediate. Antifungal agent.

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H301-H311-H331-H341
• Precautionary statements: P201-P202-P261-P264-P270-P271-P280-P302+P352-P304+P340-P308+P313-P310-P330-P361-P403+P233-P405-P501
• HS Code: 2934.99.4400