Z-vad-fmk , 98% , 161401-82-7

Synonym(s):
Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem;Z-VAD-FMK

CAS NO.：161401-82-7

Empirical Formula: C21H28FN3O7

Molecular Weight: 453.46

MDL number:

PRODUCT Properties

• Boiling point: 758.0±60.0 °C(Predicted)
• Density: 1.260±0.06 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: DMSO:5.0(Max Conc. mg/mL);11.0(Max Conc. mM)
• pka: 3.91±0.19(Predicted)
• form: Off-white solid
• color: White to light yellow

Description and Uses

Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases. This non-methylated form is useful in studies involving recombinant, isolated, or purified enzymes. Unlike the methylated form, Z-VAD(OMe)-FMK , this compound does not require pretreatment with esterases prior to in vitro use.

Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-know pan caspase inhibitor, which does not inhibit ubiquitin carboxy-terminal hydrolase L1 (UCHL1) activity even at concentrations as high as 440 μM[1].

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338