5,11-Dimethyl-6H-pyrido[4,3-b]carbazole , 98% , 519-23-3

Synonym(s):
5,11-Dimethyl-6H-pyrido[4,3-b]carbazole;Ellipticine - CAS 519-23-3 - Calbiochem

CAS NO.：519-23-3

Empirical Formula: C17H14N2

Molecular Weight: 246.31

MDL number: MFCD00010524

EINECS: 208-264-0

PRODUCT Properties

• Melting point: 316-318°C
• Boiling point: 379.31°C (rough estimate)
• Density: 1.257±0.06 g/cm3 (20 ºC 760 Torr)
• refractive index: 1.5794 (estimate)
• storage temp.: Keep in dark place,Sealed in dry,2-8°C
• solubility: DMSO: soluble
• form: Bright yellow solid
• pka: 16.59±0.40(Predicted)
• color: Light yellow to yellow
• Merck: 13,3581
• LogP: 4.800

Description and Uses

Ellipticine is an alkaloid isolated from Apocyanaceae plants that exhibits antitumor activities by intercalating into DNA and/or inhibiting DNA topoisomerase II. It forms covalent adducts in DNA after being enzymatically activated with cytochrome P450 isoforms (e.g., CYP3A4, CYP1A1, or CYP1A2) or by peroxidases in target tissues. Ellipticine has been shown to inhibit the proliferation of human breast adenocarcinoma MCF-7 cells, leukemia HL-60 and CCRF-CEM cells, neuroblastoma IMR-32, UKF-NB-3, and UKF-NB-4 cells, and U87MG glioblastoma cells with IC₅₀ values ranging from 0.27-4.7 μM.

Ellipticine is a DNA intercalating agent and exhibits antitumor activities.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P264-P270-P301+P310-P405-P501
• Hazard Codes: T
• Risk Statements: 25
• Safety Statements: 45
• RIDADR: UN 3462 6.1/PG 3
• WGK Germany: 3
• RTECS: UU8825000
• HazardClass: 6.1(b)
• PackingGroup: III
• Toxicity: LD50 in mice (mg/kg): 19.5-22.4 i.v.; 178-204 orally (Rakieten)